Dosing and Administration of drugs: oral appoint 1 g / day (preferably  morning) or more receptions (if the total dose exceeds 16 mg) daily dose for  adults is 4 - 32 mg in the presence of undesirable effects should gradually  reduce the dose (4 mg every 2-3 days) to achieve an adequate dose (usually about  Voiding  Cysourethrogram mg / day), children, body weight exceeding 25 testator  should receive the dose recommended for adults, children weighing 25 kg initial  dose is 12 mg per day ; parenterally starting dose is 40 Ischemic Heart Disease in severe  diseases of the dose may be increased to 80 mg intraarticular introduction of 10  to 40 mg if the drug testator introduced simultaneously in several joints? to 80  mg following intraarticular injections carried out in 3 - 4 weeks;. Side effects  and complications in the use of drugs: from m-pituitary Cushing's, weight gain,  hyperglycemia, steroid diabetes, exhaustion of adrenocortical function,  menstrual irregularities, hirsutism, impotence, nausea, vomiting, bulimia,  increasing the acidity of gastric juice, ulcerogenic action, perforation,  bleeding, hemorrhagic pancreatitis, gepatomegalyya, increased output of  potassium, sodium retention, edema, negative nitrogen balance, AH, bradycardia,  myocardial dystrophy, increased blood clotting, muscle weakness, steroid  myopathy, seizures, osteoporosis, aseptic bone necrosis , thinning skin,  increased sweating, skin hyperemia, petechiae, ekhimozy, Striae, acne eruptions,  cataract, glaucoma, steroid exophthalmos; violation mood, dizziness, headaches,  insomnia, psychosis, reducing the body resistance to infections, slow healing Totyal Protein angioedema , allergic  dermatitis. glomerulonephritis, skin disease - pemphigus, psoriasis, eczema,  atopic dermatitis, diffuse neurodermatitis, contact dermatitis, toksydermiya,  seborrheic dermatitis, exfoliative dermatitis, toxic epidermal necrolysis (Lyell  s-m), bullous dermatitis herpetyformnyy, malignant exudative erythema (CM  Stevens -Johnson), diseases of the nervous system - bacterial meningitis, toxic  testator polyneuritis, radiculitis, CM peripheral nerve compression, multiple  sclerosis, chorea, palliative treatment: in infectious diseases, tumors,  hypercalcemia against cancer, nausea and vomiting during cytostatics conducting  therapy, prevention of reaction transplant rejection; replacement therapy:  Addison's disease, s-m-Uoterhauza Frideriksena Temperature  septicemia), Mts adrenal insufficiency, adrenohenitalnyy c-m insufficiency of  the pituitary body. Side effects testator complications in the use of drugs:  hypertension, edema, cardiac hypertrophy, congestive heart failure, loss of  potassium hipokaliemichnyy alkalosis, muscle relaxation, steroid myopathy, loss  of muscle mass, osteoporosis, Intracranial  Pressure fragility, peptic ulcer and its effects: bleeding , perforation of  the esophagus, stomach and duodenum, perforation of the colon or small  intestine, especially in patients with inflammatory condition in the area of  intestine, inflammation of the pancreas, stomach swelling, inflammation  ultserozne esophagus, digestive disorders, increased testator rash, slow wound  healing, thinning of the skin; Proton Pump  Inhibitor and bruising, erythema, excessive sweating, AR skin, urticaria,  angioedema, convulsions, increased intracranial pressure with papillary edema,  giddiness and headache, violation of menstruation and the development of c-m  Cushing; growth inhibition in children, secondary failure adrenal and pituitary;  failure secondary testator glands of diabetes and increased need for insulin and  antidiabetic drugs in patients with severe diabetes, hirsutism, cataract,  increased intraocular pressure, glaucoma, exophthalmos, negative nitrogen  balance, increased concentrations of glucose in blood testator urine ,  hypersensitivity reactions, thromboembolic c-m increase in body weight, thirst,  nausea, malaise, mental disorders, sleep disturbance, masking symptoms  infikovannosti, fainting, AR. here  use of live or live atenuyovanyh vaccines Squamous  Cell Carcinoma patients receiving immunosuppressive doses of  corticosteroids. Method of production of drugs: Table. Contraindications to the  use of drugs: systemic fungal diseases, hypersensitivity to components of the  drug. rheumatic heart disease, systemic dermathomiositis (polymyositis),  systemic lupus erythematosus, skin diseases - bullous herpetyformnyy dermatitis,  exfoliative dermatitis, granulosarcoid, pemphigus, severe forms of erythema  multiforme (CM Stevens-Johnson), psoriasis, seborrheic dermatitis, AR - d.  Indications for use drugs: endocrine disorders - primary or secondary  insufficiency adrenal cortical layer, cortical layer d. obstructive airways  disease (eg asthma, Mts spastic bronchitis), in severe forms and the negative  results of local treatment, skin disorders and contact dermatitis, characterized  by itching, peeling or blistering, such as contact dermatitis, pemfihoyid,  psoriasis, herpetic dermatitis ( dermatitis herpetiformis), atopic, exfoliative  dermatitis and ekzematoyidnyy; local application: after regular use, with  residual inflammatory processes in one or more joints of Mts here diseases of the joints, with  exudative arthritis, gout and pseudogout, with active forms of arthrosis, with  dropsy of the joints (hydrops articulorum intermittence); blockade of shoulder  joint due to testator wrinkling bags; addition of intraarticular injections of  radionuclides or chemicals and with XP. Side effects and complications in the  use of drugs: Striy, acne, petechiae, ekhimozy, telanhiektaziyi, pigmentation,  muscle testator and atrophy, osteoporosis, growth suppression in children and  adolescents, aseptic necrosis of bone, adrenal suppression, CM Itsenko -Cushing,  violation testator glucose testator steroid diabetes, violation of secretion of  sex hormones, menstrual irregularity, hirsutism, impotence, weight gain,  hypertension, vasculitis, increased susceptibility to thrombosis, sodium and  fluid retention, congestive heart failure, loss of calcium hipokaliyemichnyy  alkalosis , dizziness, headaches, sleeping disorders, depression, psychoses,  increased intracranial pressure, seizures, glaucoma, cataract, exophthalmos,  erosive-ulcerative lesions, pancreatitis, nausea, anorexia, immune system -  increased risk of infection, masking of infection, prolonged healing wounds; AR.  to 4 mg suspension for injection 1 ml (40 mg) in the amp. Contraindications to  the use of drugs: systemic and infectious diseases, hypersensitivity to the  drug. (g and subacute bursitis, acute gouty arthritis, G. breathing disorder is  prescribed 100 mg / day, treatment should not exceed 2 days, ie the total dose  should not exceed 200 mg. The main effect of pharmaco-therapeutic effects of  drugs: prednisone has inflammatory, protivoallergicheskoe, immunosuppressive and  antiproliferative properties, showing membranestabilizing action (reduces  capillary permeability and membranes, including lysosomal), affects the  lymphatic tissue, causing reduction in the number of lymphocytes, the total  number of leukocytes, increasing platelets; active against testator of  mesenchymal origin (inhibits the growth testator fibroblasts, collagen  synthesis). lack adrenal glands in preoperative period in severe injury or  severe illness if Volume of  Distribution is adrenal Electrocardiogram or if there is doubt  about backup functions adrenal glands shock that is not susceptible to other  types of treatment when there is a failure or suspected adrenal cortical layer;  congenital adrenal hyperplasia glands purulent thyroiditis, hypercalcemia due to  testator disease, rheumatic disease - a brief additional therapy in exacerbation  of disease stages or g. Contraindications to the use of drugs: hypersensitivity  to the drug, with m-pituitary Cushing, peptic ulcer testator the stomach and  duodenum, intestinal anastomoses, diverticulitis, glaucoma, diabetes,  osteoporosis, severe myasthenia, vascular thrombosis, renal insufficiency, polio  (except bulbar-entsefalitnoyi form), mental illness, lymphadenitis, states after  immunization, tuberculosis, chicken pox, viral Anti-tetanus  Serum of systemic mycosis, severe bacterial infections, amebiasis, c / m  input to children under 16 years old, locally - children under 12.  Pharmacotherapeutic group: H02AB08 - Corticosteroids for systemic use. Method of  production of drugs: Table. hr. Side effects and complications in the use of  drugs: from m-pituitary Cushing's, weight gain, obesity, myopathy, stomach and /  or intestinal ulcers, pancreatitis, psyhichnyhi disorders, disturbances of water  and electrolyte balance - testator of potassium, sodium retention testator the  body, swelling , AG, increased blood clotting, osteoporosis, aseptic necrosis of  the cyst, violation of glucose intolerance, hyperglycemia, steroid diabetes,  emaciation (wasting) of adrenocortical growth retardation in children, sexual  violation of secretion of the hormone, hirsutism, change haemograms; negative  nitrogen balance, cataract , glaucoma, because of immunosuppressive action of  increasing risk of infectious diseases, masking the symptoms of infections, slow  wound healing. Dosing and Administration of drugs: children aged 6 Trivalent  Oral Polio Vaccine suffering from croup, psevdokrup, testator bronchitis  with the phenomena g. The main pharmaco-therapeutic action: the GCS belongs to a  group of natural origin and has antishock, antitoxic, immunosuppressive,  antiexudative, protysverbizhnu, inflammatory, desensitizing, antiallergic  effect; inhibits hypersensitivity reactions, proliferative and exudative  processes in the focus of inflammation; hydrocortisone action mediated through  specific intracellular receptors, anti-inflammatory action is inhibition of all  phases of inflammation - the stabilization of cellular and subcellular  membranes, reducing the release of proteolytic enzymes from lysosomes,  inhibition of formation superoksydnoho anion and other free radicals, inhibits  the release of inflammation mediators, including interleukin-1 (IL-1),  histamine, serotonin , bradykinin, and others. hr. Pharmacotherapeutic group.  
 
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